WebAmong exotoxins of S. aureus, TSST-1 belongs to the pyrogenic toxin class of superantigens and is a causative agent in toxic shock syndrome and septic shock [12,13]. TSST-1 is the main cause of menstrual-associated TSS and is involved in 50% of non-menstrual TSS, besides superantigens B and C [14,15,16]. WebOct 28, 2024 · Staphylococcal superantigens are virulence factors that help the pathogen escape the immune system and develop an infection. Toxic shock syndrome toxin (TSST)-1 is one of the most studied superantigens whose role in toxic shock syndrome and some particular disorders have been demonstrated. Inhibiting TSST-1 production with …
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WebMar 17, 2015 · All isolates were tested for the genes encoding Panton-Valentine leukocidin (PVL) and toxic shock syndrome toxin (TSST-1). The 2008 isolates were initially tested for PVL (lukS-PV and lukF-PV) and TSST-1 (tst) using previously described methods [39,46], then re-tested along with the 2012 isolates as follows. WebJan 6, 2024 · The patient’s therapy was switched to cefazolin (2 g every 8 h) and clindamycin (600 mg every 8 h) for 14 days based on microbiologic test results. She developed desquamation of the fingers on hospital day 8 and was diagnosed with TSS. Conventional exotoxins, such as TSST-1, and S. aureus enterotoxins were not detected in …
Toxic shock syndrome toxin-1 (TSST-1) is a superantigen with a size of 22 kDa produced by 5 to 25% of Staphylococcus aureus isolates. It causes toxic shock syndrome (TSS) by stimulating the release of large amounts of interleukin-1, interleukin-2 and tumour necrosis factor. In general, the toxin is … See more Toxic shock syndrome toxin-1 (TSST-1), a prototype superantigen secreted by a Staphylococcus aureus bacterium strain in susceptible hosts, acts on the vascular system by causing inflammation, fever, and shock. The … See more Samples of TSST-1 can be purified from bacterial cultures to use in in vitro testing environments, however this is not ideal due to the large … See more A superantigen such as TSST-1 stimulates human T cells that express VB 2, which may represent 5-30% of all host T cells. PTSAgs induce the … See more In the nucleotide sequence of TSST-1, there is a 708 base-pair open-reading frame and a Shine-Dalgarno sequence which is seven base … See more TSST-1 is a protein encoded by the tst gene, which is part of the mobile genetic element staphylococcal pathogenicity island 1. The toxin is produced in the greatest volumes during the post-exponential phase of growth, which is similar among … See more WebThe effects of tampon composition, inoculum size, and simulated menses on production of toxic shock syndrome toxin 1 (TSST-1) and toxic shock syndrome (TSS) were evaluated in a rabbit model that simulates tampon use in humans. Three small generic compressed-fiber tampons were successively inserted v …
WebApr 12, 2024 · In vivo: TSST-1 and α-toxin were only detected in tampon sections containing little or no menstrual blood, despite the high bacterial counts [86] Vβ peptides (SEB antagonists) WebThe most famous S. aureus superantigen, the 22-kD toxic shock syndrome toxin (TSST), causes TSS by stimulating release of IL-1, IL-2, TNF-α, and other cytokines. TSS is a severe and potentially fatal disease mostly known for the outbreak associated with tampon use in the 1980s. In contrast to the enterotoxin superantigens, TSST does not cause ...
WebToxic shock syndrome is caused by staphylococcal or streptococcal exotoxins. Manifestations include high fever, hypotension, diffuse erythematous rash, and multiple organ dysfunction, which may rapidly …
WebMar 1, 2006 · Antibiotic effects on the growth of Staphylococcus aureus and the production of toxic shock syndrome toxin (TSST)-1. The patient's strain of S. aureus was cultured in the absence or presence of antibiotics at the indicated final concentrations. Antibiotics were added 4 h after initiation of cultures. Bacterial growth (A) and TSST-1 production (B) were … dhr 700 body pillowWebincluding rates of colonization by TSS toxin 1 (TSST-1)-pro-ducing strains, prevalence of antibody to TSST-1, health and hygiene practices, and genetic susceptibility to the superanti-genic effects of the toxin. mTSS among women in Japan appears to be rare, with approximately 12 cases reported in the literature; however, to cinch shelterWebThese include toxic shock syndrome toxin 1 (TSST-1), enterotoxins, and exfoliative toxins (ETs). The latter are particularly interesting as the sole agents responsible for staphylococcal scalded skin syndrome (SSSS), a disease predominantly affecting infants and characterized by the loss of superficial skin layers, dehydration, and secondary … dhr99apbiap01v/reports/browse/snap projectWebMar 7, 2024 · Toxic shock syndrome (TSS) is a serious infection caused by Staphylococcus aureus [1, 2] and Streptococcus pyogenes [3,4,5], with occasional cases associated with Groups B, C and G streptococci [6,7,8,9].Superantigens, which include toxic shock syndrome toxin-1 (TSST-1), staphylococcal enterotoxin serotypes B and C, and streptococcal … dhr99acsaddi01/addicse/casesearchWebNational Center for Biotechnology Information dhr 2 on frontWebOct 8, 2024 · Toxic shock syndrome (TSS) is a toxin-mediated acute life-threatening illness, usually precipitated by infection with either Staphylococcus aureus or group A Streptococcus (GAS), ... signaling drive the epithelial response to Staphylococcus aureus toxic shock syndrome toxin-1 (TSST-1). J Biol Chem. 2012 Sep 21. 287(39):32578-87. dhr 7000 body pillowWebTSST-I appears to be an important toxin in TSS. Factors supporting this statement include (1) the observation that more than 90 percent of isolates from patients with TSS produce TSST-I, (2) the absence of acute-phase antibody to TSST-I in more than 90 percent of patients with menstrual TSS, (3) ... dhr 99th readiness division