The pregnane x receptor
WebbPregnane X Receptor (PXR) belongs to the nuclear receptors’ superfamily and mainly functions as a xenobiotic sensor activated by a variety of ligands. PXR is widely expressed in normal and malignant tissues. Drug metabolizing enzymes and transporters are also under PXR’s regulation. Antineoplastic agents are of particular interest since cancer … Webb2 okt. 2024 · Nuclear receptors such as the Pregnane X Receptor (PXR) are known to be key regulators of ABC drug transporters such as Abcb1, Abcc2, Abcc3, and Abcg2 [ 25, 26, 27, 28 ]. It is well known that PXR is activated by endogenous steroidal hormones and their metabolites, the levels of which are dramatically elevated during pregnancy.
The pregnane x receptor
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Webb1 apr. 2024 · It is well-known that the pregnane X receptor (PXR)/Nr1i2 is a critical xenobiotic-sensing nuclear receptor enriched in liver and intestine and is responsible for … Webb1 nov. 2006 · The pregnane X receptor (PXR) is a major chemical sensor known to activate the expression of CYP3A/Cyp3a in humans and rodents. The purpose of this study is to …
Webb1 feb. 2024 · The pregnane X receptor (PXR) is a nuclear receptor which regulates drug metabolizing enzymes (DMEs) by activation from endogenous, as well as exogenous, … WebbThe pregnane X receptor (PXR) is a member of the nuclear receptor family of ligand-regulated transcription factors. Like many former orphan nuclear receptors, it contains …
Webb18 mars 2009 · Pregnane X receptor (PXR) is an important component of the body's adaptive defense system responsible for the elimination of various toxic xenobiotics. … Webb10 sep. 2024 · Pregnane X Receptor (PXR) is a ligand-activated transcription factor which binds many structurally different molecules. The receptor is able to regulate the …
Webb15 juli 2008 · Background: The pregnane X receptor (PXR; NR1I2), a member of the nuclear receptor superfamily, regulates the expression of metabolic enzymes and transporters …
WebbPregnane X receptor Function . PXR belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by... Ligands . PXR is activated by a … greenheart growers fifeWebbThe nuclear pregnane X receptor (PXR; NR1I2) is an important component of the body's adaptive defense mechanism against toxic substances including foreign chemicals … greenheart furniture ltdWebb10 mars 2024 · Cheng J, Krausz KW, Tanaka N, Gonzalez FJ (2012a) Chronic exposure to rifaximin causes hepatic steatosis in pregnane X receptor-humanized mice. Toxicol Sci … flutter rust wasmflutter sample app githubWebbPregnane X Receptor (PXR), a member of the nuclear receptor (NR) superfamily, discovered in 1998 , represents a modular protein sharing common regions, a highly … greenheart games twitterhttp://www.paper.edu.cn/scholar/showpdf/MUT2QNyIMTD0YxeQh greenheart group limitedWebb21 jan. 2024 · 孕烷X受体. 孕烷X受体(pregnane X receptor,PXR)是核受体超家族成员之一。其主要功能是感知外来有毒物质的存在，并相应地上调参与解毒和清除这些物质的蛋白 … flutter scaffold back button