Webb10 aug. 2024 · Taken together, these data identify a novel pathway governing CHK1-mediated regulation of PLK1 activity during mitosis. RESULTS CHK1 is a target of PIM2 … Webb4 apr. 2024 · PLK1 Induces Chromosomal Instability and Overrides Cell-Cycle Checkpoints to Drive Tumorigenesis. PLK1 regulates hepatic stellate cell activation and liver fibrosis …
Overcoming PLK1 inhibitor resistance by targeting mevalonate …
Webb5 aug. 2015 · To the best of our knowledge, this is the first evidence to suggest that Plk1 is necessary for the activation of the MAPK pathway in smooth muscle cells upon growth factor stimulation. In response to activation with growth factors, ERK1/2 gets phosphorylated at Thr-202/Tyr-204, which is catalyzed by the dual-specificity protein … Webb1 apr. 2012 · Polo-like kinase 1 (Plk1) is a key mitotic regulator that modulates the G 2 –M transition by affecting the activation of phosphatase CDC25C and cyclin B1 ( 2–4 ). Plk1 is overexpressed in a number of malignancies including … geothermal energy potential in china
PathCards :: PLK1 signaling events Pathway and related pathways …
WebbC2: Curated CP: Canonical Pathways CP:PID: PID Pathways Source publication Pubmed 18832364 Authors: Schaefer CF,Anthony K,Krupa S,Buchoff J,Day M,Hannay T,Buetow KH WebbOur data suggest that PLK1 inhibition restores sensitivity to PARPi in HGSOC with KRAS amplification. The sequential combination of PLK1 inhibitor ... While it rarely contains KRAS mutations, it shows RAS pathway activation in about 25% of tumors [8,9] and KRAS amplification in 13.9% of patients, ... Webb1 juli 2007 · LOS ANGELES Novel modulators of the polo-like kinase 1 (Plk1) pathway targeting the cell cycle may be effective as anticancer agents. Several of these new … geothermal energy potential in texas